8.8
HIGH CVSS 4.0
CVE-2026-31968
HTSlib CRAM decoder vulnerable to buffer overflow
Description

HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data using a variety of encodings and compression methods. For the `VARINT` and `CONST` encodings, incomplete validation of the context in which the encodings were used could result in up to eight bytes being written beyond the end of a heap allocation, or up to eight bytes being written to the location of a one byte variable on the stack, possibly causing the values to adjacent variables to change unexpectedly. Depending on the data stream this could result either in a heap buffer overflow or a stack overflow. If a user opens a file crafted to exploit this issue it could lead to the program crashing, overwriting of data structures on the heap or stack in ways not expected by the program, or changing the control flow of the program. It may be possible to use this to obtain arbitrary code execution. Versions 1.23.1, 1.22.2 and 1.21.1 include fixes for this issue. There is no workaround for this issue.

INFO

Published Date :

March 18, 2026, 8:16 p.m.

Last Modified :

March 18, 2026, 8:16 p.m.

Remotely Exploit :

Yes !
Affected Products

The following products are affected by CVE-2026-31968 vulnerability. Even if cvefeed.io is aware of the exact versions of the products that are affected, the information is not represented in the table below.

No affected product recoded yet

CVSS Scores
The Common Vulnerability Scoring System is a standardized framework for assessing the severity of vulnerabilities in software and systems. We collect and displays CVSS scores from various sources for each CVE.
Score Version Severity Vector Exploitability Score Impact Score Source
CVSS 4.0 HIGH [email protected]
Solution
Update HTSlib to a patched version to fix heap or stack overflow vulnerabilities.
  • Update HTSlib to version 1.23.1 or later.
  • Apply patches for versions 1.22.2 or 1.21.1 if applicable.
  • Validate file integrity before processing.
References to Advisories, Solutions, and Tools

Here, you will find a curated list of external links that provide in-depth information, practical solutions, and valuable tools related to CVE-2026-31968.

URL Resource
https://github.com/samtools/htslib/commit/0ec436796eca7b4ce7fcc9b77270c102da29bb2e
https://github.com/samtools/htslib/security/advisories/GHSA-cgcm-c9r2-p57j
CWE - Common Weakness Enumeration

While CVE identifies specific instances of vulnerabilities, CWE categorizes the common flaws or weaknesses that can lead to vulnerabilities. CVE-2026-31968 is associated with the following CWEs:

Common Attack Pattern Enumeration and Classification (CAPEC)

Common Attack Pattern Enumeration and Classification (CAPEC) stores attack patterns, which are descriptions of the common attributes and approaches employed by adversaries to exploit the CVE-2026-31968 weaknesses.

We scan GitHub repositories to detect new proof-of-concept exploits. Following list is a collection of public exploits and proof-of-concepts, which have been published on GitHub (sorted by the most recently updated).

Results are limited to the first 15 repositories due to potential performance issues.

The following list is the news that have been mention CVE-2026-31968 vulnerability anywhere in the article.

The following table lists the changes that have been made to the CVE-2026-31968 vulnerability over time.

Vulnerability history details can be useful for understanding the evolution of a vulnerability, and for identifying the most recent changes that may impact the vulnerability's severity, exploitability, or other characteristics.

  • New CVE Received by [email protected]

    Mar. 18, 2026

    Action Type Old Value New Value
    Added Description HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data using a variety of encodings and compression methods. For the `VARINT` and `CONST` encodings, incomplete validation of the context in which the encodings were used could result in up to eight bytes being written beyond the end of a heap allocation, or up to eight bytes being written to the location of a one byte variable on the stack, possibly causing the values to adjacent variables to change unexpectedly. Depending on the data stream this could result either in a heap buffer overflow or a stack overflow. If a user opens a file crafted to exploit this issue it could lead to the program crashing, overwriting of data structures on the heap or stack in ways not expected by the program, or changing the control flow of the program. It may be possible to use this to obtain arbitrary code execution. Versions 1.23.1, 1.22.2 and 1.21.1 include fixes for this issue. There is no workaround for this issue.
    Added CVSS V4.0 AV:N/AC:L/AT:N/PR:N/UI:N/VC:N/VI:H/VA:L/SC:N/SI:N/SA:N/E:X/CR:X/IR:X/AR:X/MAV:X/MAC:X/MAT:X/MPR:X/MUI:X/MVC:X/MVI:X/MVA:X/MSC:X/MSI:X/MSA:X/S:X/AU:X/R:X/V:X/RE:X/U:X
    Added CWE CWE-787
    Added CWE CWE-121
    Added CWE CWE-122
    Added CWE CWE-843
    Added Reference https://github.com/samtools/htslib/commit/0ec436796eca7b4ce7fcc9b77270c102da29bb2e
    Added Reference https://github.com/samtools/htslib/security/advisories/GHSA-cgcm-c9r2-p57j
EPSS is a daily estimate of the probability of exploitation activity being observed over the next 30 days. Following chart shows the EPSS score history of the vulnerability.